Mechanisms of Drug Resistance in Neoplastic Cells. - download pdf or read online

By Paul V. Woolley

ISBN-10: 0127633626

ISBN-13: 9780127633626

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Additional info for Mechanisms of Drug Resistance in Neoplastic Cells. Bristol–Myers Cancer Symposia, Volume 9

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Details are given in Rice et al. (1986). 3. 5 hr after the 10-min BrdU pulse and shows that the G 2/ M cells have progressed into G{, a portion of the Gx cells have progressed into S. Also, those cells that were in late S phase (they have increased fluorescence) have divided and now constitute cells with G{ DNA content. The cells that were in early S phase at the time of pulse labeling are now in late S phase (BrdU fluorescence) with DNA content progressing to G 2 / M levels. Figure 3e shows cells 24 hr after exposure to hypoxia (compare Fig.

Berge, J. , and Georghiou, G. P. (1986). Amplification of an esterase gene is responsible for insecticide resistance in a Culex mosquito from California. Science 233, 7 7 8 - 7 8 0 . Rice, G. C , Hoy, C , and Schimke, R. T. (1986). Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells. Proc. Natl. Acad. Sei. A. 83, 5 9 7 8 - 5 9 8 2 . Salmon, S. , Hamburger, H. , Durie, B. G. , Ahlberts, D. S. and Moon, Τ. E. (1978). Quantitation of differential sensitivity of human-tumor stem cells to anticancer drugs.

The effect of having many of the divisions result in differentiated cells (that have limited proliferative capacity) will be to slow the overall doubling time of the cell system to a value much less than the potential doubling time if all cell divisions resulted in viable stem cells. If we define P, the renewal probability, as the probability that a single stem cell will divide to form two stem cells, then it can be shown that the doubling time (DT) is given by Thus, the lower the renewal probability, the slower will be the overall doubling time of the system if the generation time of the clonogenic cells remains un- 2.

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Mechanisms of Drug Resistance in Neoplastic Cells. Bristol–Myers Cancer Symposia, Volume 9 by Paul V. Woolley


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