By A. F. Hofmann (auth.), K. Rommel, H. Goebell, R. Böhmer (eds.)
In may perhaps 1975 greater than 50 scientists - study employees and clinician- from 12 nations spent 3 days at Titisee within the Black wooded area discussing difficulties on the subject of lipid absorption and methods of selling nearer liaison within the box. during this ebook the entire papers provided at this symposium are released in complete, including the resultant discussions. we should always all wish to thank Dr Falk for his beneficiant sponsorship of this assembly which enabled us to paintings in this type of captivating surroundings. we should always additionally prefer to thank the authors and the opposite members for the quick coaching and correction in their manuscripts, and the publishers for his or her cooperation and assistance in getting ready this e-book. We think it repre sents a wide-ranging survey of latest wisdom of lipid absorption on the way to, we belief, supply a true stimulus for extra examine and new principles within the research of this subject.
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Additional resources for Lipid Absorption: Biochemical and Clinical Aspects: Proceedings of an International Conference held at Titisee, The Black Forest, Germany, May 1975
The chains of the lipids are in a 'melted' state (Chapman, 1968). g. , 1972). The fluidity of the lipids of a cell membrane is related to factors such as the chain length, amount of unsaturation of the chains and also the class of lipids present. , 1974). , 1967; Kornberg and McConnell, 1971). , 1973). g. in the red blood cell membrane the lecithin and sphingomyelin lipids are predominantly on the outside surface whilst the phosphatidylethanolamine and phosphatidyl/serines are arranged on the inside surface (Bretscher, 1972).
Chem. Phys. , Nir, S. and Isac, T. (1973). Phase transitions in phospholipid vesicles. Fluorescence polarization and permeability measurements concerning the effect of temperature and cholesterol. Biochim. Biophys. Acta, 311, 330 Small, D. , Penkett, S. A. and Chapman, D. (1969). Studies on simple and mixed bile salt micelles by nuclear magnetic resonance spectroscopy. Biochim. Biophys. Acta, 176, 178 44 Discussion 3 Dr Dawson: Dr Desnuelle: Dr Chapman: Dr Desnuelle: Dr McIntyre: Dr Chapman: Thank you very much indeed.
1. If the resistance to membrane penetration is dominant (R M > Ro) the gradient from C 1 to C2 will be shallow, but the gradient from C2 to C3 will be steep (Dietschy, 1973). Since the interfacial concentration, C2, cannot be measured directly, one must rely on indirect evidence to show the relative importance of Ro and RM in determining uptake. Let us consider first Ro' the aqueous diffusional resistance. No matter how vigorously a bulk medium is stirred a layer adjacent to any interface remains virtually undisturbed.
Lipid Absorption: Biochemical and Clinical Aspects: Proceedings of an International Conference held at Titisee, The Black Forest, Germany, May 1975 by A. F. Hofmann (auth.), K. Rommel, H. Goebell, R. Böhmer (eds.)