Download e-book for iPad: Handbook of Clinical Pediatric Endocrinology, Second Edition by Charles G. D. Brook, Mehul T. Dattani(auth.)

By Charles G. D. Brook, Mehul T. Dattani(auth.)

ISBN-10: 047065788X

ISBN-13: 9780470657881

ISBN-10: 1119968151

ISBN-13: 9781119968153

Content material:
Chapter 1 The Relevance of Molecular Biology to scientific perform (pages 1–14):
Chapter 2 Hormones: Their Nature, motion and size (pages 15–30):
Chapter three The Hypothalamo?Pituitary Axis (pages 31–47):
Chapter four Endocrine difficulties of Infancy (pages 48–69):
Chapter five The administration of progress issues (pages 70–98):
Chapter 6 The administration of Puberty problems (pages 99–128):
Chapter 7 The Thyroid Gland (pages 129–150):
Chapter eight The Adrenal Gland (pages 151–174):
Chapter nine problems of Calcium and Bone Metabolism (pages 175–209):
Chapter 10 Water stability (pages 210–229):
Chapter eleven Hypoglycemia (pages 230–247):
Chapter 12 weight problems and sort 2 Diabetes Mellitus (pages 248–266):
Chapter thirteen style 1 Diabetes Mellitus (pages 267–295):
Chapter 14 Endocrine Neoplasia (pages 296–308):
Chapter 15 exams and basic Values in Pediatric Endocrinology (pages 309–324):

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Extra resources for Handbook of Clinical Pediatric Endocrinology, Second Edition

Example text

However, its concentration is altered in a number of other disease states such as hypothyroidism, malnutrition, poorly controlled diabetes and chronic disease. INDD 34 Isolated growth hormone deficiency Congenital GH deficiency encompasses a group of different etiological disorders. It may occur in isolation or associated with other anterior and posterior pituitary hormone deficiencies with or without extrapituitary features such as optic nerve hypoplasia and midline forebrain defects. The condition may be sporadic or familial.

Its actions include stimulation of the iodide pump on the cell membrane transporting iodide into the cell, stimulation of the synthesis of the thyroidal storage protein thyroglobulin, and stimulation and synthesis of T4 and T3 and their release from their complexes with thyroglobulin. Isolated thyroid-stimulating hormone deficiency Central hypothyroidism has a reported prevalence of 1 in 50,000 livebirths. Neonates can present with non-specific 1/30/2012 11:21:03 PM CHAPTER 3 The Hypothalamo-Pituitary Axis symptoms such as lethargy, poor feeding with failure to thrive, prolonged hyperbilirubinemia, and cold intolerance.

The α-subunit is identical to the α-subunit of TSH and the specific biological activity of both hormones resides in the β-subunit. The human chorionic gonadotropin β-subunit has similar biological activity to the LH β-subunit. LH secretion is pulsatile in both sexes but sexual dimorphism in physiological secretory patterns becomes evident with maturity of the hypothalamopituitary-gonadal axis. An increased nocturnal LH release is the first sign of the onset of puberty. Pulsatile release of hypothalamic GnRH regulates the secretion of LH and FSH which stimulate the testis and ovary at puberty to increase the gonadal steroid secretion and develop secondary sexual characteristics.

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Handbook of Clinical Pediatric Endocrinology, Second Edition by Charles G. D. Brook, Mehul T. Dattani(auth.)

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