By Harold Papkoff (auth.), Joyce W. Lustbader Ph.D., David Puett Ph.D., Raymond W. Ruddon M.D., Ph.D. (eds.)
Advances within the box of glycoprotein hormones necessitated a moment foreign symposium in this subject, held March eleven to fourteen, 1993, in Santa Barbara, California, and back subsidized by way of Serono Symposia, united states. The assembly was once twofold in its notion: (1) the dissemination of the present examine within the box and (2) honoring 3 scientists who've enormously contributed to this box, Drs. Harold Papkoff, Robert Ryan, and Darrell Ward, upon their retirements. We have been venerated to have Dr. John Pierre current as a player on the assembly and in addition serving as grasp of ceremonies on the ceremonial dinner. one among the highlights on the first assembly, held in 1989, was once the cloning of the CG/LH receptor. This moment assembly was once additionally choked with insightful and cutting edge medical displays. major advances within the legislation of gene transcription of the gonadotropins have been offered by way of Pamela Mellon, James Hoeffler, John Nilson, Bruce Weintraub, and Joel Habener. those shows mirrored significant advances from the within the figuring out techniques provided on the final assembly. different advances of hormone structure/function integrated the continued paintings through Joyce Lustbader at the decision of the third-dimensional constitution of hCG, together with a brand new strategy utilizing nonisotopic labels for three-D and 4-D NMR imaging. New insights into biosynthesis of hCG have been proposed through Irving Boime. reports directed at picking receptor touch areas have been awarded via Henry Keutmann and David Puett.
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Additional info for Glycoprotein Hormones: Structure, Function, and Clinical Implications
4. Glenn SD, Nahm HS, Ward DN. The amino acid sequence of the rabbit lutropin beta subunit. J Prot Chern 1984;3:259-73. 5. Ward DN, Bousfield GR, Mar AO. Chemical reduction-reoxidation of the glycoprotein hormone disulfide bonds. In: Bellet D, Bidart JM, eds. Structurefunction relationship of gonadotropins. New York: Raven Press, 1989:119. 6. Cornell JS, Pierce JG. Studies on the disulfide bonds of glycoprotein hormones: locations in the a chain based on partial reductions and formation of 14C-labeled S-carboxymethyl derivatives.
In support of the role for GSEB in regulating the LH~-subunit gene, this protein is also expressed in an immortalized mouse gonadotrope cell line that expresses the endogenous mouse LH~ subunit gene (unpublished observations). Coordinate Expression of Gonadotropin Subunit Genes These findings suggest that the regulation of the glycoprotein hormone subunit genes may be coordinated within each cell type that expresses them through the participation of common tissue-specific regulatory proteins. Coordinate expression of multiple genes through the use of a common regulatory protein is known in the pituitary in the case of the POU-homeodomain protein, Pit-1 (or GHF-1), which is involved in activation of both the growth hormone and prolactin genes (20, 21)~ Furthermore, in the erythroid cell lineage, a single transcriptional regulatory protein, GATA-1, activates a variety of erythroid-specific genes, including the globin genes (11).
Fortunately, this developmental program can be duplicated in vitro by serum starving proliferating myoblast cells, causing them to fuse into myotubes. It was shown that a single cDNA can convert fibroblasts, which never express muscle-specific genes or fuse, into myotubes (4). This demonstrated that a single protein could act as a "master switch" and initiate the skeletal muscle development program in a nonmuscle cell. Once cloned, this cDNA, named MyoD, was shown to be a sequence-specific DNA binding protein, and it was shown that MyoD binding sites were present in the promoters of the muscle-specific genes (5).
Glycoprotein Hormones: Structure, Function, and Clinical Implications by Harold Papkoff (auth.), Joyce W. Lustbader Ph.D., David Puett Ph.D., Raymond W. Ruddon M.D., Ph.D. (eds.)