By Willi Bannwarth, Berthold Hinzen, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
The hot version of this practice-oriented instruction manual gains completely up to date contents, together with fresh advancements in parallel synthesis. a brand new bankruptcy on screening enhances the evaluate of combinatorial procedure and artificial tools. "Experimental information and whole response information ... are a continuing topic operating via this work". (Angewandte Chemie). "Recommended to novices within the box of combinatorial chemical synthesis as a result of its wide scope". (Journal of the yankee Chemical Society). Read more... Purification rules in high-speed solution-phase synthesis / Steffen Weinbrenner, C. Christoph Tzschucke -- Linkers for solid-phase natural synthesis (SPOS) and combinatorial techniques on strong helps / Willi Bannwarth -- Cyclative cleavage : a flexible notion in solid-phase natural chemistry / Josef Pernerstorfer -- C-C bond-forming reactions / Wolfgang K.-D. Brill, Gianluca Papeo -- Combinatorial synthesis of heterocycles / Eduard R. Felder, Andreas L. Marzinzik -- Polymer-supported reagents : training and use in parallel natural synthesis / Berthold Hinzen, Michael G. Hahn -- Encoding ideas for combinatorial libraries / Berthold Hinzen -- Automation and units for combinatorial chemistry and parallel natural synthesis / Christian Zechel -- Computer-assisted library layout / Andreas Dominik -- Assays for high-throughput screening in drug discovery / Christian M. Apfel, Thilo Enderle
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Extra info for Combinatorial chemistry : from theory to application
4. Fig. 4 9 10 1 Purification Principles in High-Speed Solution-Phase Synthesis Most widely used are N,N’-dialkylimidazolium salts, since they are easily prepared. Ionic liquids have been used as solvents for numerous reactions. Their physical and chemical properties vary with the combination of cation and anion. This allows a degree of tuning of their properties. Since they are highly polar solvents, ionic liquids can dissolve many inorganic salts and transition metal complexes, and often form biphasic mixtures with non-polar organic solvents.
The yield of the release step should not depend on the synthesized structure. This is of particular concern if equimolarity of the released products is required. Finally, it should be mentioned that synthesis of the linker unit – if this is not available commercially – should be straightforward, and that coupling of the starting material should proceed without great difficulty. 2 describes linkers for the attachment of particular functional groups, while subsequent sections describe principles applied during the attachment and release of compounds, for example metathesis.
3). Another method is the use of adsorbent packing cartridges to adsorb the aqueous phase (Na2SO4, MgSO4, alumina, EXtrelut®). Furthermore, a hydrophobic membrane or frit (PTFE) in a polypropylene cartridge can be used to separate a dichloromethane or chloroform phase from an aqueous phase (Fig. 1). The dichloromethane or chloroform phase can pass through the frit, while the aqueous phase remains on top of the filter. Another separation method involves cooling of the organic/aqueous phase to –20 °C in deep-well plates in the presence of pins.
Combinatorial chemistry : from theory to application by Willi Bannwarth, Berthold Hinzen, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers