Download PDF by Michael Baum, Craig Henderson: Classic Papers in Breast Disease

By Michael Baum, Craig Henderson

ISBN-10: 0203640667

ISBN-13: 9780203640661

ISBN-10: 0203693051

ISBN-13: 9780203693056

ISBN-10: 1901865835

ISBN-13: 9781901865837

Every one quantity within the vintage Papers sequence offers as much as 200 of crucial papers released in a specific forte. The papers were rigorously compiled, no longer purely for his or her old value but additionally for his or her modern relevance. during this quantity, vintage Papers in Breast sickness, a group of specialists stocks their adventure in learning, diagnosing and treating breast affliction. The remark, continually insightful and simple, levels from conception to perform, from actual to mental. for instance, experts speak about molecular biology and endocrinology in addition to the mental elements of the illness and steps clinicians can take to control ache.

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Subsequent work led to the discovery of the first breast cancer gene (BRCA1). Related references (1) Easton DF, Bishop DT, Ford D, Crockford GP, and the Breast Cancer Linkage Consortium. Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. American Journal of Human Genetics 1993; 52:678–701. (2) Ford D, Easton DF, Peto J. Estimates of the gene frequency of BRCA1 and its contribution to breast and ovarian cancer incidence. American Journal of Human Genetics 1995; 57:1457– 1462.

New York: Hafner Publishing Co, 1966 Summary This was a comprehensive treatise on a range of aspects of the design of experiments. The general goal was to provide designs which eliminated bias and reduced random error. There are extensive sections on complex combinatorial designs such as Latin squares and partially replicated factorial designs, but there are also crucial basic sections on the importance of randomization and a discussion of the ability of replication to minimize random errors. Sections 9–11 on randomization and replication are fundamental and chapter IV (sections 22–30) which describes the randomized block design are particularly relevant.

The need for large numbers of patients to detect moderate treatment differences led to the development of the overview of all trials addressing the same question. The importance of collecting and updating follow-up on an individual patient basis was first demonstrated by Cuzick et al. (Paper 9) and led to important changes in the use of radiotherapy. Larger efforts, looking at all aspects of breast cancer treatment, were subsequently undertaken by the Early Breast Cancer Trialists Collaborative Group and an important exposition of overview methodology was published in one of their early reports (Paper 12).

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Classic Papers in Breast Disease by Michael Baum, Craig Henderson


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