By S. B. Field (auth.), Dr. med. Dipl. biochem. Rolf D. Issels, Prof. Dr. med. Wolfgang Wilmanns (eds.)
Physicians, biologists and physicists current their contemporary paintings within the box of hyperthermia in regards to either its software and its blend with radiation and chemotherapy. present technical chances, scientific administration and significant features of its use for superficial and deep-seated tumors are mentioned. the most subject matters mentioned are: adjustments of metabolism and microcirculation lower than warmth stipulations, the organic interplay of warmth with X-rays and several other chemotherapeutic brokers, and the latest scientific facts from diversified associations at the mixed software within the therapy of cancer.
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Extra resources for Application of Hyperthermia in the Treatment of Cancer
After heat treatment for 3 h at 42° C higher glutathione levels were observed. The GSH levels were about 10%-25% higher than in untreated MeWo cells. After hyperthermia the GSSG contents in the MeWo cells were increased about 30%-50% in comparison to the controls. The ratios of GSH to GSSG were about 25% lower after heat treatment than in untreated MeWo cells (Table 1). Table 1 also shows glutathione levels in xenografts of these cells in nude mice before and after hyperthermia. In the tumour the GSH levels also increased slightly after heat treatment.
Table 2. 4 The GSH contents in Be 11 cells are three times higher than in Me Wo cells. Directly after hyperthermia the amounts of GSH were the same in both heat-treated and untreated Be 11 cells, but it increased during the period 48-96 h in heat-treated cells (data not shown). An increase of about 20%-40% in the level of GSSG was observed after hyperthermia compared to untreated cells (Table 2). Table 2 shows the GSH and GSSG levels in Be 11 tumours and Be 11 cells after heating. The GSH levels in both xenografts and Be 11 cells were not significantly affected directly after hyperthermia.
Elsevier, Amsterdam, pp 60-63 Fink RM, Lengfelder E (1987) Hyaluronic acid degradation by ascorbic acid and influence of iron. Free Radiat Res Commun, (in press) Hahn GM (1982) Hyperthermia and cancer. Plenum, New York, pp 232-242 Hukins DWL (1984) Connective tissue matrix. Verlag Chemie, Weinheim Isseis RD, Biaglow JE, Epstein L, Gerweck LE (1984) Enhancement of cysteamine cytotoxicity by hyperthermia and its modification by catalase and superoxide dis mutase in Chinese hamster cells. Cancer Res 44: 3911-3915 Isseis RD, Fink RM, Lengfelder E (1986) Effects of hyperthermic conditions on the reactivity of oxygen radicals.
Application of Hyperthermia in the Treatment of Cancer by S. B. Field (auth.), Dr. med. Dipl. biochem. Rolf D. Issels, Prof. Dr. med. Wolfgang Wilmanns (eds.)