Jean D. Sipe's Amyloid Proteins: The Beta Sheet Conformation and Disease PDF

By Jean D. Sipe

A first-stop reference on proteins linked to amyloidosis. This ebook is the 1st to give a scientific assessment of all identified fibril-forming proteins, together with their biochemical features and pathophysiology. It considers the clinically famous amyloid proteins which are recognized to be linked to the amyloid protein folding issues, facing their universal structural and thermodynamic positive factors that bring about amyloid fibril formation and affliction. Emphasis is at the thermodynamics of protein folding, the constitution and physiologic results of universal oligomeric and subfibrillar intermediates and the impression of the extracellular matrix and mobile trafficking and metabolism at the genesis and catabolism of beta pleated sheet proteins. The chapters on particular amyloid proteins all stick with a typical constitution, permitting easy access to the specified biochemical and scientific facts, making this a useful software for clinicians and researchers alike.

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Extra info for Amyloid Proteins: The Beta Sheet Conformation and Disease

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J. Liepnieks, M. Yazaki, T. Yamashita, K. Hamidi Asl, B. Guenther and B. Kluve-Beckerman. A new human hereditary amyloidosis: the result of a stop-codon mutation in the apolipoprotein AII gene. Genomics 2001, 72, 272–277. 23 24 1 Amyloidosis and Amyloid Proteins: Brief History and Definitions 129 Benson, M. , J. Liepnieks, T. Uemi- 130 131 132 133 134 135 136 chi, G. Wheeler and R. Correa. Hereditary renal amyloidosis associated with a mutant fibrinogen alpha-chain. Nature Genetics 1993, 3, 252–256.

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Mandema, L. Ruinen, H. Scholten and A. S. Cohen (eds). Excerpta Medica, Amsterdam, 1968, p. 80. Shirahama, T. and A. S. Cohen. Highresolution electron microscopic analysis 19 20 1 Amyloidosis and Amyloid Proteins: Brief History and Definitions 48 49 50 51 52 53 54 55 56 57 of the amyloid fibril. J Cell Biol 1967, 33, 679–708. Shirahama, T. and A. S. Cohen. Reconstitution of amyloid fibrils from alkaline extracts. J Cell Biol 1967, 35, 459–464. Shirahama, T. and A. S. Cohen. A brief review of the ultrastructure of amyloid.

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Amyloid Proteins: The Beta Sheet Conformation and Disease by Jean D. Sipe

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