By B.-E. Wiholm (auth.), Dr. Michael Kurowski (eds.)
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Extra info for Adverse Reactions to Non-Steroidal Anti-Inflammatory Drugs: Clinical Pharmacoepidemiology
Med. 290: 1158 (1974). 15. , Aspirin, paracetamol and haematemesis and melena. Gut 23: 340 (1982). 16. , Major upper gastrointestinal bleeding. Relation to the use of aspirin and other non-narcotic analgesics. Arch . Intern. Med. 148 : 281 (1988). 17. W, personal communication (1990). 18. , Aspirin and bleeding peptic ulcers in the elderly. Br. Med. J. 297: 1311 (1988). 19. Aspirin Myocardial Infarction Study Research Group, A randomized, controlIed trial of aspirin in persons recovered from myocardial infarction .
163-175. Adverse Reactions 10 NSAlD: ClinicaJ PhaJmacoepäemiology 00. Kurowski © 1992 Bir1lhäuser Verlag Basel Post-Marketing Surveillance as an Instrument of Adverse Drug Reaction Monitoring H. Kewitz Institute of Clinical Pharmacology, Klinikum Steglitz der Freien Universität Berlin, Hindenburgdamm 30, D-W-IOOO Berlin 45, Germany Post-marketing surveillanee (PMS) of drugs involves a number of procedures for observing and registering the benefits and risks of drugs following their approval for general use.
The efficiency of case-control studies decreases when exposure is rare. Case-control stud ies have become the main source of most current epidemiological research on the causes of disease [5,6]. The methodological issues relevant to the design of case-control studies are based on common scientific principles: rigorous definition of the event to be studied and of the criteria for measuring of drug exposure (taking into account the etiologically-relevant period), systematic ascertainment of cases, proper selection of controls, and consideration of validity.
Adverse Reactions to Non-Steroidal Anti-Inflammatory Drugs: Clinical Pharmacoepidemiology by B.-E. Wiholm (auth.), Dr. Michael Kurowski (eds.)